Though not a particularly large city and certainly tamer than the likes of BA, Argentina’s wine capital has the ability to keep you thoroughly entertained until sunrise, provided you know where to look. It’s worth bearing in mind that some clubs here (Scanner, for example, located in El Challao just northwest of the city) are only open seasonally, so your best bet for a wild night out on the town is in the heat of the summer months (December - March). That said, you should be able to find enough watering holes here serving up drinks year round to keep your liver well exercised.
If there’s one name to remember in Mendoza, it’s Aristides Villanueva (as in Avenue Aristides Villanueva). This popular strip, which runs east to west just southwest of the city center, is packed with lively bars and restaurants (Basilika, Por Aca, etc.), and is the city’s go to when the clock strikes midnight. To be sure, there are plenty of cool bars scattered throughout the downtown area, like Blah Blah Bar which specializes in cocktails and other delicious libations on Maipu, or the live music emanating from Café Soul (San Juan 456); however, if you’re looking to frequent a few different establishments without walking far, Villanueva is the way to go.
For the club lover in all of us, your best bet is to hop in a cab and head southwest towards the suburb of Chacras de Coria. There are some options northwest in the El Challao neighborhood as well, but they're fewer and farther between. Once you drop either name to your cabbie he should know where to take you, but it never hurts to get a tip or two from knowledgeable locals as to which venue is hottest on which night. And should you not feel like venturing that far from the city center, there are one or two weekend clubs rocking in and around the downtown area. Names like Apeteco and Iskra are a good place to start, so choose your poison wisely and see where a night out in western Argentina takes you.