Sure. Perth will not win any international awards for nightlife excess or ever be seen as on the same level as travel destinations like Melbourne, Brisbane, or Sydney, but at least you won't ever be at a loss in finding an establishment to meet your taste. It is also much quieter and safer here in general, with the guys at the bar yelling at the tv during the local AFL game being as rowdy as it gets.
To break Perth down by nightlife areas and streets would be a questionable endeavor, especially because there isn't just one or two places where you can stroll between an ever-popular mass of establishments, although weekends in the CBD do tend to get packed as the late evening progresses into night; just be aware that many bars will close by 12pm in many areas of the city, so don't expect an all-night experience.
There are plenty of good bars and pubs around, especially in areas like Fremantle and the CBD, while those looking for a good time on the dance floor can find them in both the CBD and in Northbridge, where fixtures like Ambar, Capitol Nightclub, and Metro City fit the bill.
For a city this size, you'd expect a somewhat larger nightlife scene; then again, it's a reflection of its people, who would often rather hit up a drive-through liquor store and do their drinking in the leisure of their own homes. Still, you won't be at a loss if you decide to head out for a night on the town, especially on the weekend, when the selection of bars, clubs, and music venues is plenty enough to meet the needs of a world traveler.