About three miles long and central to both the Little Italy district on its western end and the Toronto student scene on its eastern, you'll find that good, local food will never be hard to dig up. Frank's Kitchen and Hey Meatball! are great choices in Little Italy for a good lunch or dinner, while Utopia has stellar burgers and La Carnita kills it Mexican-style. Try veering south on Augusta for a ton more eating options.
Then again, for those about to rock and/or dance, plenty of hip joints from dives to club spaces host live music. Sneaky Dee's, Andy Poolhall and Mod Club are huge if your interest lies here, otherwise bars of all varieties are quite ubiquitous, particularly in the few blocks between Manning and Beatrice.