Running from Victoria Street at its north end to the Deansgate railway station at its southern, Deansgate is the longest route in central Manchester, providing an important thoroughfare to the city's cultural milestones. Then again, this street could just as easily be a destination in its own right; there are shopping malls, famous buildings (John Rylands Library and Beetham Tower), and plenty of opportunity for nightlife and cuisine. These last two will be our main focus here.
The Deansgate neighborhood that surrounds the avenue bearing the name is great for varied cuisine; from upscale steakhouses and international fine dining to simpler cafe grub and take-out, there are options galore within just a few blocks of where you may be. The intersections with both Peter Street and Bridge Street are good choices if you're looking to veer off in search of food.
If you endeavor to explore Manchester's nightlife, Deansgate has an assortment of establisments; the excellent BrewDog chain has a Peter Street location, Mojo is the nightclub of choice, and the Gaslamp is a basement bar where live music is popular. Of course, if you're looking for a lot of options in a smaller area, then the Deansgate Locks at the road's southern terminus are a premiere destination. Comedy and dance clubs, pubs, and cocktail lounges all sit beneath the refurbished archways of the Bridgewater Canal, making for a classier and more expensive night out if that's your style.