The only way to explore the western coast of Jamaica, Norman Manley Boulevard begins in Negril and follows the coast north through Bloody Bay, providing access to innumerable resorts, bars, and local cuisine. Oh yeah, and beaches. You've got like, a gazillion miles of sand and water. You can't miss it.
Many of you will be staying in the aforementioned resorts if you're traveling to Negril and there will invariably be beach access, food, and a bar near the water. Still, it may suit you to seek out other establishments along Norman Manley; Margaritaville has a big name and will be packed with tourists, while live music and volleyball are the appeal at Alfreds Ocean Palace. Jungle is the one nightclub that has managed to stick around for a while and will be your dance music fix while establishments like Ossie's will take care of that jerk chicken fix.
We would suggest any other streets in Negril if there were any; the only one where you can get a decent mix of food, drink, and fun is Norman Manley Boulevard.
Note:It is also imperative to check out Bloody Bay at the northern end of the Norman Manley; it's a short hike from Negril, but it is an area that values beach life, fresh food (seafood even), and cold drinks. With such a combination, you can't go wrong.